First Description of the Default Mode Network (2001) - Marcus Raichle and colleagues published their discovery of a network of brain regions that are active when the mind is at rest, revolutionizing understanding of the brain's baseline activity.
Publication of "The Emotional Brain" (1996) - Joseph LeDoux published his groundbreaking work on the neural circuits of fear and emotion, transforming understanding of emotional processing and memory formation during emotional experiences.
First Use of Optogenetics in Living Animals (2005) - Karl Deisseroth and colleagues published their pioneering technique for controlling specific neurons with light, revolutionizing neuroscience by allowing precise manipulation of neural circuits.